![]() Moreover, rapid on-site evaluation of material has optimized specimen collection and triage. Hence, these endoscopy-guided procedures are now considered to be fine-needle biopsies. This has become particularly important today with greater sample procurement from deep body sites made possible due to the advent of newer biopsy techniques (e.g., fiber optic endoscopy) and next generation needles (e.g., SharkCore). As a result, modern sophisticated methods have been able to generate cell-blocks with superior cellular yields, including the preservation of small tissue fragments. Ĭell-block preparation methods have evolved considerably over the years. Today, cytology laboratories routinely prepare cell-blocks for a variety of cytology specimen types such as body cavity fluids, washings, and fine needle aspirations (FNA) as a part of an integrated cytology diagnosis. Most opted for a more selective approach based on their anticipated need for ancillary testing. Subsequently, many laboratories began preparing cell-blocks for various specimen types. utilized cell-blocks for fluid specimens and concluded that by allowing for histologic pattern recognition these preparations improved cancer diagnosis. Cell-block preparation allows for the retrieval of small sample fragments in cytology specimens that often cannot be processed by other cytologic techniques (e.g., direct smear, and liquid-based preparations). This review article discusses the benefit of various architectural patterns identifiable in cell-blocks employed as an adjunct to Pap tests, exfoliative fluid specimens, and fine-needle aspirations.Ĭell-blocks are essentially microbiopsies that are formalin fixed and embedded in paraffin. This new era of “cytohistology” accordingly requires practicing cytologists to become more familiar with histopathology. Microscopic examination of cell-blocks is quick, avoids obscuring material, permits cells to be evaluated in one focal plane, and allows the histologic architecture such as glandular differentiation, papillary formations, and sometimes invasion to be easily identified. ![]() A cell-block compatible sample may thus obviate the need for a more invasive procedure such as a tissue biopsy. ![]() They represent concentrated, cell-enriched preparations that provide cytologists with the opportunity to evaluate cellular architecture, as well as to perform ancillary testing. Cell-blocks allow retrieval of small tissue fragments from cytology specimens that sometimes cannot be processed by alternate cytologic techniques. This has become more prevalent with greater sample procurement due to the advent of newer biopsy techniques and needles. They are essentially microbiopsies that are formalin fixed and embedded in paraffin. Cell-block preparations have become an essential part of integrated cytology diagnosis.
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